Nausea and vomiting, whether due to chemotherapy, AIDS treatment, abdominal surgery, or another cause, can be effectively remedied through the use of medical marijuana. Clinical trials and patients' experiences indicate that smoking medical marijuana can both relieve nausea and stimulate the appetites of patients with nausea, reducing the risk of unhealthy weight loss in patients with conditions like cancer and AIDS.

The anti-nausea effects of medicinal marijuana are well known both scientifically and among users who have experienced relief from nausea and vomiting. While cannabinoids isolated from the cannabis plant also help to mitigate nausea, smoking medical marijuana provides superior treatment for vomiting when compared to THC ingested orally. THC also improved appetite and reduced weight loss in patients living with AIDS, as a 2007 study showed. In a similar study during the same year in which scientists surveyed HIV-positive marijuana smokers, both THC and medical marijuana resulted in an increase in caloric intake and in weight.

While synthetic THC in oral form provides some of the benefits of smoked medical marijuana, many patients prefer to smoke or vaporize cannabis instead of taking a THC pill. Cannabis is a fully renewable resource and, depending upon local marijuana laws, patients may be permitted to grow medical marijuana at home rather than traveling to a pharmacy for their medication. In 1991, 54% of clinical oncologists surveyed felt that their patients should be able to obtain medical marijuana by prescription for nausea and other symptoms.

Medical marijuana is even effective for some patients whose nausea does not respond to traditional antiemetic medications. In one study published in the New York State Journal of Medicine, fifty-six patients were treated whose nausea symptoms had not responded to traditional antiemetic drugs. Of these fifty-six patients, 78% saw improvement after smoking medical marijuana.

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